abstract：:Cutaneous adverse drug reactions comprise a significant proportion of all adverse drug reactions. They may mimic other dermatologic or systemic illnesses and may cause significant morbidity or mortality. Seven morphologic groups encompass the most commonly encountered cutaneous drug reaction syndromes: exanthematous (...

journal_title：Drugs & aging

authors： Young JWS,Shear NH

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Previous studies of antihypertensive treatment of older patients have focused on blood pressure control, cardiovascular risk or adherence, whereas data on inappropriate antihypertensive prescriptions to older patients are scarce. OBJECTIVES:The aim of the study was to assess inappropriate antihypertensive...

journal_title：Drugs & aging

authors： Márquez PHP,Torres OH,San-José A,Vidal X,Agustí A,Formiga F,López-Soto A,Ramírez-Duque N,Fernández-Moyano A,Garcia-Moreno J,Arroyo JA,Ruiz D,Potentially Inappropriate Prescription in Older Patients in Spain (PIPOPS) Investigators

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:The use of proton pump inhibitors (PPIs) in older adults is high, often inappropriate, and may cause harm. Deprescribing is defined as the reduction, withdrawal, or discontinuation of inappropriate medication. OBJECTIVE:We conducted a systematic review to determine the effectiveness of interventions to depr...

journal_title：Drugs & aging

authors： Wilsdon TD,Hendrix I,Thynne TR,Mangoni AA

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Poor medication adherence is a major public health problem in older adults often resulting in negative health outcomes. OBJECTIVE:The objective of this review was to provide an updated summary of evidence from randomized controlled studies to determine whether interventions aimed at improving medication adh...

journal_title：Drugs & aging

authors： Marcum ZA,Hanlon JT,Murray MD

更新日期：2017-03-01 00:00:00

abstract：:Colonoscopy is an important diagnostic and screening tool for colorectal cancer detection and prevention, and adequate bowel preparation is critical for successful colonoscopy. Complications related to colonoscopy, either directly or indirectly related to the procedure, are increased in elderly patients, and the risks...

journal_title：Drugs & aging

authors： Ho SB,Hovsepians R,Gupta S

更新日期：2017-03-01 00:00:00

abstract：:Urinary incontinence is a common and debilitating problem, and post-prostatectomy incontinence (PPI) is becoming an increasing problem, with a higher risk among elderly men. Current treatment options for PPI include pelvic floor muscle exercises and surgery. Conservative treatment has disputable effects, and surgical ...

journal_title：Drugs & aging

authors： Løvvik A,Müller S,Patel HR

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:For physicians dealing with patients with a limited life expectancy, knowing the time to benefit (TTB) of preventive medication is essential to support treatment decisions. OBJECTIVE:The aim of this study was to investigate the usefulness of statistical process control (SPC) for determining the TTB in relat...

journal_title：Drugs & aging

authors： van de Glind EM,Willems HC,Eslami S,Abu-Hanna A,Lems WF,Hooft L,de Rooij SE,Black DM,van Munster BC

更新日期：2016-05-01 00:00:00

abstract：:Elderly rheumatoid arthritis (RA) is classified into two clinical subsets, elderly-onset RA (EORA) and younger-onset elderly RA. With the improvement of life expectancy in the general population and advent of the super-aging society, the number of patients with EORA is anticipated to increase. Both large and small joi...

journal_title：Drugs & aging

authors： Sugihara T,Harigai M

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Frailty is a clinical phenotype that is associated with adverse health outcomes. Since frail patients may be more prone for adverse drug events and about 15-20 % of commonly prescribed drugs are metabolized by CYP2D6, we hypothesized that CYP2D6 metabolism is decreased in frail patients compared with healthy...

journal_title：Drugs & aging

authors： Opdam FL,Modak AS,Mooijaart SP,Louwerens M,de Waal MW,Gelderblom H,Guchelaar HJ

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Improvement in renal function and decreases in serum uric acid (SUA) have been reported following prolonged high-intensity statin (HMG-CoA reductase inhibitor) therapy. This post hoc analysis of the SAGE trial examined the effect of intensive versus less intensive statin therapy on renal function, safety, an...

journal_title：Drugs & aging

authors： Deedwania PC,Stone PH,Fayyad RS,Laskey RE,Wilson DJ

更新日期：2015-12-01 00:00:00

abstract：:Overactive bladder (OAB) is a common constellation of lower urinary tract storage symptoms that causes a significant impact on a person's quality of life. The elderly may be disproportionally impacted by these symptoms due to concomitant poor mobility, comorbid conditions such as diabetes and heart failure, and polyph...

journal_title：Drugs & aging

authors： McFerren SC,Gomelsky A

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Immunosenescence makes the elderly more susceptible to influenza complications and less responsive to vaccination. An intradermal formulation (IDflu) is one of several strategies being investigated to increase the immunogenicity of influenza vaccines. OBJECTIVE:The overall goal of the study was to assess ...

journal_title：Drugs & aging

authors： Pileggi C,Mascaro V,Bianco A,Nobile CG,Pavia M

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Statins have been shown to be beneficial in primary and secondary prevention settings; however, their role in the elderly remains a clinical conundrum, given that age-related factors could alter the risk-benefit ratio of statin treatment. This study aimed to critically evaluate the efficacy and safety of sta...

journal_title：Drugs & aging

authors： Teng M,Lin L,Zhao YJ,Khoo AL,Davis BR,Yong QW,Yeo TC,Lim BP

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Several studies have shown that the mortality of elderly hip fracture patients is higher than that in the general population, and is higher in male than in female hip fracture patients. OBJECTIVE:The objective of this study was to investigate factors affecting overall mortality at a minimum of 11 years foll...

journal_title：Drugs & aging

authors： Nurmi-Lüthje I,Lüthje P,Kaukonen JP,Kataja M

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Limited data are available on the prevalence of inappropriate prescribing of renally cleared drugs in elderly patients in Australia. OBJECTIVES:To quantify and compare the extent of inappropriate prescribing (defined as at least one drug prescribed in an excessive dose or when contraindicated with respect t...

journal_title：Drugs & aging

authors： Khanal A,Peterson GM,Castelino RL,Jose MD

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Inappropriate medications are often used in older adults despite their unfavourable risk-to-benefit profile. Although many of the medications in the American Geriatrics Society (AGS) Beers list are potentially inappropriate because of their anticholinergic properties, little is known regarding the nature and...

journal_title：Drugs & aging

authors： Kachru N,Carnahan RM,Johnson ML,Aparasu RR

更新日期：2015-05-01 00:00:00

abstract：:The 2013 American College of Cardiology (ACC) and American Heart Association (AHA) practice guidelines for the treatment of blood cholesterol significantly changed the paradigm of how providers should prescribe statin therapy, especially for older adults. While the evidence supports statin therapy for older adults wit...

journal_title：Drugs & aging

authors： Weinberger Y,Han BH

更新日期：2015-02-01 00:00:00

abstract：:The use of antimicrobial agents has increased in recent years as treatments have diversified and resistant bacteria have appeared. With increased use of antimicrobial agents, elderly patients are prone to adverse drug reactions (ADRs) as a result of factors such as drug-drug interactions, polypharmacy, long-term use, ...

journal_title：Drugs & aging

authors： Mizokami F,Mizuno T

更新日期：2015-01-01 00:00:00

abstract：:Neuropathic pain (NeP) is a significant medical and socioeconomic burden with limited therapeutic options. Elderly patients exhibit a higher incidence of several NeP conditions and pose a particular challenge due to age-related pharmacokinetic and pharmacodynamic issues, comorbid conditions, and polypharmacy, as well ...

journal_title：Drugs & aging

authors： Sawynok J

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Patients with congestive heart failure (CHF) have a high prevalence of cognitive impairment and the association is multifactorial. In general, the burden of anticholinergic drugs has consistently been shown to be a risk factor for cognitive impairment in the elderly. The aim of this study was to a...

journal_title：Drugs & aging

authors： Shaukat A,Habib A,Lane KA,Shen C,Khan S,Hellman YM,Boustani M,Malik AS

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:Older adults receiving cytotoxic agents may be more susceptible to hematologic toxicities because of progressive reduction in organ functions and multiple co-morbidities. Because older adults are under-represented in clinical trials, this retrospective study aims to evaluate hematologic toxicity of gemcitabine-...

journal_title：Drugs & aging

authors： Crombag MR,de Vries Schultink AH,Schellens JH,Beijnen JH,Huitema AD

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Older people often take multiple medications. It is a policy priority to facilitate older people to stay at home longer. Three-quarters of nursing home placements in the US are preceded by a hospitalization. OBJECTIVE:To investigate the association between polypharmacy and medication regimen complexity with...

journal_title：Drugs & aging

authors： Wimmer BC,Dent E,Visvanathan R,Wiese MD,Johnell K,Chapman I,Bell JS

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Medication for elderly patients is often complex and problematic. Several criteria for classifying inappropriate prescribing exist. In 2010, the Swedish National Board of Health and Welfare published the document "Indicators of appropriate drug therapy in the elderly" as a guideline for improving prescribing...

journal_title：Drugs & aging

authors： Hovstadius B,Petersson G,Hellström L,Ericson L

更新日期：2014-05-01 00:00:00

abstract：:Aflibercept is a fully human, recombinant fusion protein that acts as a soluble decoy receptor for vascular endothelial growth factor (VEGF) family members, including VEGF-A, VEGF-B and placental growth factor (P1GF), thereby inhibiting downstream signalling mediated by these ligands. Aflibercept binds all isoforms of...

journal_title：Drugs & aging

authors： Yang LP,McKeage K

更新日期：2014-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic movement disorder typically coupled to progressive degeneration of dopaminergic neurons in the substantia nigra (SN). The treatments currently available are satisfactory for symptomatic management, but the efficacy tends to decrease as neuronal loss progresses. Neurotrophic factor...

journal_title：Drugs & aging

authors： Rodrigues TM,Jerónimo-Santos A,Outeiro TF,Sebastião AM,Diógenes MJ

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:By using the findings obtained from the PREPARED study, we aimed to estimate the cost effectiveness of ropinirole prolonged release (PR) [Requip-Modutab(®)] in Parkinson's disease (PD) versus ropinirole immediate release (IR). In the PREPARED study, ropinirole PR provided a significantly greater improvement ...

journal_title：Drugs & aging

authors： van Boven JF,Novak A,Driessen MT,Boersma C,Boomsma MM,Postma MJ

更新日期：2014-03-01 00:00:00

abstract：:Research into the use of clozapine in older people is somewhat scarce. Clozapine is associated with serious adverse effects such as agranulocytosis, seizures, myocarditis and metabolic syndrome. Other common undesirable effects such as sedation, constipation (which can be fatal), urinary incontinence and hypersalivati...

journal_title：Drugs & aging

authors： Bishara D,Taylor D

更新日期：2014-01-01 00:00:00

abstract：:Healthcare systems worldwide are facing an unprecedented demographic change as globally, the number of older people will triple to 2 billion by the year 2050. The resulting pressures on acute services have been instrumental in the development of intermediate care (IC) as a new healthcare model, which has its origins i...

journal_title：Drugs & aging

authors： Millar AN,Hughes CM,Passmore AP,Ryan C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Over three-quarters of the older population take medications that can potentially cause dry mouth. Physicians or pharmacists rarely inform patients about this adverse effect and its potentially severe damage to the teeth, mouth and general health. OBJECTIVES:The objectives of this study were to (1) identify...

journal_title：Drugs & aging

authors： Nguyen CT,MacEntee MI,Mintzes B,Perry TL

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Treatment of postherpetic neuralgia (PHN) is more complicated in elderly patients, and multiple daily dosing, complex titration, and high incidences of adverse events can be limiting for many pharmacological treatment options. OBJECTIVE:The aim of this study was to determine whether the efficacy and tolerab...

journal_title：Drugs & aging

authors： Gupta A,Li S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Older people are exposed to multiple medicines that possess anticholinergic properties. The use of anticholinergic medicines is associated with the risk of morbidity, mortality and cognitive decline, particularly in older people. Anticholinergic exposure can be measured using tools such as the Drug Burden In...

journal_title：Drugs & aging

authors： Narayan SW,Hilmer SN,Horsburgh S,Nishtala PS

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Previous studies have investigated the prevalence of drug-drug interactions (DDIs) among the elderly in different care settings, but data describing the frequency and management of DDIs among acute geriatric patients appear to be absent. OBJECTIVE:The aim of this study was to investigate the severity and in...

journal_title：Drugs & aging

authors： Lea M,Rognan SE,Koristovic R,Wyller TB,Molden E

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Clinical validation studies of the Healthcare Effectiveness Data and Information Set (HEDIS®) measures of inappropriate prescribing in the elderly are limited. OBJECTIVES:The objective of this study was to examine associations of new exposure to high-risk medication in the elderly (HRME) and drug-disease in...

journal_title：Drugs & aging

authors： Pugh MJ,Marcum ZA,Copeland LA,Mortensen EM,Zeber JE,Noël PH,Berlowitz DR,Downs JR,Good CB,Alvarez C,Amuan ME,Hanlon JT

更新日期：2013-08-01 00:00:00

abstract：:Decitabine (Dacogen(®)) is a deoxynucleoside analogue of cytidine that selectively inhibits DNA methyltransferases. Decitabine administered at a dose of 20 mg/m(2) by a 1-h intravenous infusion for 5 consecutive days of a 4-week cycle has been approved by the European Medicines Agency (EMA) for use in adult patients a...

journal_title：Drugs & aging

authors： Curran MP

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:The aims of the study were to evaluate usage rates of warfarin in stroke prophylaxis and the association with assessed stages of stroke and bleeding risk in long-term care (LTC) residents with atrial fibrillation (AFib). METHODS:A cross-sectional analysis of two LTC databases (the National Nursing Home Surv...

journal_title：Drugs & aging

authors： Reardon G,Nelson WW,Patel AA,Philpot T,Neidecker M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Osteoarthritis (OA) is a highly prevalent and chronic condition characterized by pain and physical disability. Currently, many treatments are available, and they primarily target pain relief. The objectives of this study were to systematically review economic evaluations for pharmaceutical mana...

journal_title：Drugs & aging

authors： Xie F,Tanvejsilp P,Campbell K,Gaebel K

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Glaucoma comprises age-related neurodegenerative diseases of retinal ganglion cells, the worldwide prevalence of which is increasing. Local pharmacotherapy is the primary treatment option, especially in the elderly. But this therapeutic approach may include risks for adverse drug effects and drug-drug intera...

journal_title：Drugs & aging

authors： Huber M,Kölzsch M,Stahlmann R,Hofmann W,Bolbrinker J,Dräger D,Kreutz R

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Pharmacotherapy with statins (HMG-CoA reductase inhibitors) is the cornerstone for lipid management in individuals with or at risk of developing cardiovascular diseases. Although the clinical benefits of statins are established for both women and men, there is evidence of a gender difference in their use. Th...

journal_title：Drugs & aging

authors： Bhattacharjee S,Findley PA,Sambamoorthi U

更新日期：2012-12-01 00:00:00

abstract：:Melatonin prolonged release (PR) 2 mg is approved for the treatment of primary insomnia characterized by poor sleep quality in patients aged ≥55 years in the EU and elsewhere. Patients may receive treatment with melatonin PR for up to 13 weeks. Production of endogenous nocturnal melatonin, which helps regulate circadi...

journal_title：Drugs & aging

authors： Lyseng-Williamson KA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Remifentanil used in combination with propofol provides adequate conditions for tracheal intubation without muscle relaxants. Delivery of the optimal dose is important to prevent poor intubation conditions and drug-related complications. No previous study has investigated the use of a remifentanil-propofol c...

journal_title：Drugs & aging

authors： Goo EK,Oh AY,Cho SJ,Seo KS,Jeon YT

更新日期：2012-11-01 00:00:00